äҵء (Hog Cholera, Classical Swine Fever, CSF : A 130)

ҵء äкҴçͧءë觹Ӥ٭·ҧɰԨɵáҧҡ ͧҡäкҴǴԴѺء÷ءѵҡû¤͹ҧ٧ ǹѵҡõ¢ѺعçͧäԤѹäͧء ѧɵáè֧ûͧѹԴä㹿
˵ äԴҡ öժԵҹҾǴá ç͹ 觻ͧ ѵ ʨж١èӾǡҧ ⫴ Фի
          õԴСкҴͧä Դµçҡءûǡѹ ⴹʨж١Ѻ͡ҡѺ觢Ѻ ١ ب л ҨԴͷҧҡ ѵ§ ˹ ŧ ҹ˹з㹡âء͡ҡ
          ҡ ءû¨ʴҡѧҡѺͻҳ 1 ѻ ҡû¢ѺعçͧԤѹäءе
          ء÷ѺʪԴعçҡʴҡẺѨغѹ ٧ ˹ ͹ѹ ͵ѡʺ ١ ӵ áͧءèзͧ١ еҨзͧǧ ѡҡ÷ҧҷ Թ ѧҵЪѡ㹪ǧ ء÷äẺѧѺͪԴعç ҡâͧä蹪Ѵ ֧Ҩѧࡵ ¨硹 ҡҹ˹СѺ繢ա ءè Һ дҧ ѡաõԴẤá͹ ʹ ʹѡʺе㹷ش ء÷Ѻ͢е駷ͧз١ ʹ١͡ ١ءõáʹ ǹ١ء÷ʹԵ ͹ҡ÷ҧҷ ١ءҹ繾зӤѭ㹡ä

١ءù͹ѹ ըشʹ͡ ¨ʹǧ˹ѧ

          ԡä شʹ͡dz˹ѧ ੾о鹷ͧ١ ⤹Ҵҹ ԴҴ ըشʹ͡ ͧ ͧ§ Сл ʹ١شѹ ¹͡ѡɳ繨ʹӤ
          äǺäлͧѹä
          1. ѴôҹآԺ١آѡɳ §ء˹Թ ӤҴءҧ ӨѴ ˹ ŧҧ 繾ТͧäлͧѹõԴͨ¹͡Ҧä͹ҿ
          2. մѤչͧѹäء÷ءǵзͧء÷Ѥչдǡ㹡õǨͺѧ
          3. éմѤչء÷ءТͧõ駷ͧ ͧҡöҹҡѧ١¼ҹҧá ʨὧ١ء÷Ѥչͧѹä١ءҹ
          4. ѧѤչسҾ Ѥչ١Ը 㹵͡еԡ秷դ§١ʧᴴ
          5. ءû·ʧä ¡㹤͡ѵ·ҧ·ѹպ駵ͻѵͻѵѧѴ Тͤйӷ١ͧ㹡äǺä
          6. ءû äШ¾駷ӤҴءô⫴ 2% ͤի 5% ǻҧҳ 2 ѻ͹ء§

          äҵءäͧءءûҷ Դҡ (family Flaviviridae, genus Pestivirus) пѡǹҹ 2- 14 ѹ ͷҾҡҹ ѧ鹨֧ҨժԵ㹼Եѳ÷ҹѹ Ընúҧҧ õԴäԴҡµçѺ ʹ 觢Ѻ äѴ觨ҡѵ͵ ͨҡҹá١ء õ÷§ءҹ 㹿ԴäЪШǡѺ ҹ˹-͡ ͼ ͡к͡մ ç͹ ͧͧҧ ١ء÷Դ͵ԴöҹѺ͹ͧҡСõԴ㹡ʹ (persistence viraemia) ҧ·ҧҡ ͺص ͪҧ ˹ѧաҴ ʹ üѹ

Ҧäҵء ի δ͡䫴 2% Թ 1% ๵ (4% anhydrous 10% ֡ crystalline Ѻѡ͡ա 1%) ѡ͡ ( 駪Դ ionic non-ionic detergent) ⴿҧç 1% 㹡ô ʿ

äԸѡ ѵ¤ö١ǽѧҫҡ 㹻ȷѧäѤԹ繫Ŵ㹡ûͧѹ٭ҨӨѴä ǹȷʹä͡áӨѴäդ˹ҨӡéմѤԹ äǺͧѹäŴյͧդҧ˹ҷѰ ѵᾷҢͧ к§ҹäջԷҾ ǴùءժԵмԵѳ áѡѹء͹٧ õ§ءô äǺçӨѴҡѵ ӡѧä㹿-ѹ кúѹ֡зͧ·ء աкҴ÷ء÷ء㹿 ӨѴҡѵ 觻ٹ͹ ͽѧ зҴ ˹ࢵäкҴ Ǻ͹ءзӡѧä ԹͺǹҧкҴԷ觷СáШ¢ͧä

㹡ѧä (Case Definition for Surveillance)

1. ࡳҧԹԡ (Clinical Criteria)
1.1 Դºѹ (Acute form)
- 41 C Թ ͹
- ˹ѧʹ͡繨ش 繼ᴧ (multifocal hyperaemia and haemorrhagic lesions)
- ˹ѧͺͻдӤ (cyanosis) ҧ ١ ¢
- ءҡ÷ͧ١ǢС͹ҡ÷ͧµ ҧ¹
- Ӻҡ
- ҡ÷ҧҷ ҵ ѡ
- ͹ѹ
- ѧҡʴҡ 5 -15 ѹ ءѵҵҨ֧ 100%

1.2 Դѧ (Chronic form)
- Թ Ҩҡ÷ͧ¹ҹ֧͹
- ͹ء» СѺաе㹷ش

1.3 ԴԴԴ (Congenital form)
- ҡ蹵Դ ͹
- ù ⵪ е㹷ش
- ءҡû 㹡ʹ ·ҧԤä

1.4 Դعç (Mild form)
- Ǣ Թ
- ١㹷ͧж١ٴ ʹ١͡ ͤʹ͡ҵ
- ʹ١ء÷ԴԴ
- Ҩ١

2.   ࡳҧͧԺѵԡ (Laboratory criteria)
2.1   ԡ (Lesions)
2.1.1 Դºѹ (Acute form)
- ʹǵ (leucopaenia & thrombocytopaenia)
- ʹ͡繨ش (petechiae and ecchymoses) Ш·੾з˹ѧ ͧ ͧ§ л µҧ硡Ѻ˭ (ileocaecal junction)
- Ҩ͵·ͺ繨ش
- ѡͧ˭ʹ͡
- ͧѡʺ perivascular cuffing

2.1.2 Դѧ (Chronic form)
- ͧ͡ (buttonulcers) ˭ caecum
- lymphoid tissue ջҳŴŧ
- ԡѡʺʹ͡ѡ

  2.1.3 ԴԴԴ (Congenital form)
- ͧԴ central dysmyelinogenesis, cerebellar hypoplasia mycroencephaly
- ʹԭԺ Pulmonary hypoplasis
- Դا (hydrops)
- ҧ蹷Դ (malformations)

2.2 ԸԹԨͧԺѵԡ
- Virus Identification Ը Direct immunofluorescence Ѻ (cryostat section) ҡ͹ ͧ (pharyngeal mesenteric) ǹ¢ͧ ileum ʹءû EDTA
- Virus isolation cell culture ǵǨʴԸ immunofluorescence immunoperoxidase õǨ׹ѹ monoclonal antibodies
- Serological tests Ը Neutralisation peroxidase-link essay, Fluorescent antibody virus neutralization , ELISA 纫ҡѵ ءäʹ١ʧҨеԴ͵Դ (suspected congenitally infected litters) ء÷ӡѧä

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::ͧ͡ʶҺѹآҾѵ觪ҵ кҴԷҷҧѵᾷ ӹѡǺ ͧѹ кӺѴäѵ ѵ зǧɵˡó
Reference / 觷Ң : OIE Technical Disease Card (updated : 22.04.2002)